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KMID : 0358419920350071017
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Korean Journal of Obstetrics and Gynecology
1992 Volume.35 No. 7 p.1017 ~ p.1023
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Sister Chromatid Exchange Induced by Diethylstibestrol in Lymphocytes from Pregnant, Premenopausal & Postmenopausal Women
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방현주/Bang HZ
박현미/최영득/김흥곤/김기석/Park HM/Choi YD/Kim HG/Kim KS
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Abstract
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The present study was undertaken to examine the effect of Diethylstilbestrol on the induction of the sister chromatid excahange in lymphocytes from pregnant (4 to 6 month), premenopausal, postmenopausal women and normal men. The results were as follows; 1. DES induced SCEs in lymphocytes from pregnant and premenopausal women, but had only a slight effect at the highest(4×10 M) concentration in lymphocytes from men and postmenopasual women. 2. The average number of SCEs was higher in lymphocytes from pregnant women than in those from premenopausal women. 3. DES strongly inhibited cell proliferation in lymphocytes from both a man and a pregnant woman. 4. When lymphocytes from a man & a pregnant woman were cocultured in the presence of DES, only the lymphocytes of the woman responded with an increase in SCEs. The above results suggest that the ability of DES to induce SCEs in lymphocytes is related to the hormonal state of the individual and that cells from premenopausal women especially, pregnant women show an increased susceptibility to DES.
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KEYWORD
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